Full Title RECOMBINANT DRUG DEVELOPMENT AND ENGINEERING

Short Title RECOMBINANT DRUG ENGINEERING

Code BIO08048
Level 08
Credit 05

Author Butler, Mary
Department Life Sciences

Subject Area Bio Tech/Eng/Chem
Attendence N/A%
Fee

Description
The subject aim is to introduce the students to the drug discovery and development process. The subject will compare traditional pharmaceutical drug development to biopharmaceutical drug development. The module will include an in depth study of the different modes and methods of recombinant protein expression in different cellular hosts. The module will introduce the analysis and manipulation of recombinant protein expression in the biopharmaceutical sector.

Indicative Syllabus
Drug Discovery.

Overview of key molecular biological processes and techniques.

Recombinant protein expression.

Recombinant protein analysis, characterization and manipulation.

Recombinant expression experiments in cell lines by different techniques.

Learning Outcomes
On completion of this module the learner will/should be able to
  1. Differentiate between irrational and rational drug design. Describe the methods of drug target identification and validation.

  2. Outline the molecular methods and components required to characterize and clone the gene of interest.

  3. Categorize the essential steps in the design and regulation of a recombinant expression system.

  4. Describe methods employed to optimize nucleic acid sequence and cell expression systems for maximum protein expression including methods to optimize the molecular characteristics of purified proteins

  5. Examine methods of verifying the functional and molecular characteristics of the recombinant protein.

  6. Illustrate methods of production of humanized monoclonal antibodies and phage display libraries.

  7. Perform analysis of a recombinant protein


Assessment Strategies
The miniproject is a MANDATORY form of assessment for any modules on this programme with a miniproject component.

Module Dependencies
Pre Requisite Modules
Molecular Biology
Co Requisite Modules
None
Incompatible Modules
None

Coursework Assessment Breakdown %
Course Work / Continuous Assessment 70 %
End of Semester / Year Formal Examination 30 %

Coursework Assessment Breakdown

Description Outcome Assessed % of Total Assessment Week
Continuous Assessment Short questions on theory lecture content. 1,2,3,4 15 Week 4
Practical Evaluation Short questions on experimental data 7 15 Week 8
Individual Project Literature project 2,3,4,5,6 40 OnGoing


End Exam Assessment Breakdown

Description Outcome Assessed % of Total Assessment Week
Essay Theory exam 1,2,3,4,5,6,7 30 End of Term


Distance Learning Mode Workload

Type Location Description Hours Frequency Avg Weekly Workload

Total Average Weekly Learner Workload 0.00 Hours

Part Time Mode Workload

Type Location Description Hours Frequency Avg Weekly Workload
Lecture Distance Learning Suite Online lectures 2 Weekly 2.00
Independent Learning Not Specified Project work and study 5.5 Weekly 5.50

Total Average Weekly Learner Workload 2.00 Hours

Full Time Mode Workload

Type Location Description Hours Frequency Avg Weekly Workload

Total Average Weekly Learner Workload 0.00 Hours

Online Learning Mode Workload

Type Location Description Hours Frequency Avg Weekly Workload

Total Average Weekly Learner Workload 0.00 Hours

Resources
Book Resources
Biotechnology and Biopharmaceuticals: Transforming Genes into Drugs. Author: Rodney, J.Y.Ho. Wiley-Liss 2003

Gene Cloning and DNA Analysis: An Introduction. Author Brown, T.A. Oxford Blackwell 2006

Drugs: From Discovery to Approval. Author: Rick, N.G., Wiley-Liss Press. 2004
Other Resources
None
Url Resources
Additional Info