Full Title BIOPHARMACEUTICAL SCIENCE PRACTICAL

Short Title BIOPHARMA PRACTICAL

Code BIO08037
Level 08
Credit 10

Author Butler, Mary
Department Life Sciences

Subject Area Bio Tech/Eng/Chem
Attendence N/A%
Fee

Description
This Biopharma laboratory practical module will provide students with practical knowledge, know-how and practical skills associated with biopharmaceutical operations. The relevant learning is achieved through the completion of a sequence of laboratory-based and pilot-plant based practicals and experiments that are designed to impart the required expertise. There will also be some research project work associated with the laboratory practicals.

Indicative Syllabus
The range of lab-based and pilot-plant based upstream practicals may include some or all of the following items: aseptic techniques; cell culture techniques including cell counting, sub-culturing, thawing up and freezing-down of cells; bioreactor inoculation and operation, sampling and substrate analysis. P ID (Piping and Instrumentation Diagrams) analysis work on bioreactor systems; CIP and SIP cycle operation on bioreactor systems.



The range of lab-based and pilot-plant based downstream practicals covered may include some or all of the following items: filter integrity testing; centrifugation; buffer preparation; chromatography; protein concentration using ultrafiltration; protein concentration and buffer exchange using diafiltration; column packing; theory and practice of industrial-scale chromatography skids.



The range of lab-based and pilot-plant based aseptic processing practicals may include some or all of the following items: contamination control; vial filling; filling line operation; glove integrity testing and environmental monitoring.

Learning Outcomes
On completion of this module the learner will/should be able to
  1. Demonstrate a range of practical know-how and skills associated with relevant, lab-based and pilot-plant based upstream bioprocessing equipment.

  2. Demonstrate a range of practical know-how and skills associated with relevant, lab-based and pilot-plant based downstream bioprocessing equipment.

  3. Perform some defined research project work related to the lab. practicals and interpret and critically evaluate the data and results obtained from this project work. 

  4. Take responsibility for and direct the work of other individuals in a quasi-GMP environment.

  5. Demonstrate effective communication skills both orally and in written format.


Assessment Strategies
The assessment strategy will comprise of both observation of skills being acquired as well as formal assessment of knowledge acquisition. There will be a project research element associated with the assessment strategy also.

The miniproject is a MANDATORY form of assessment for any modules on this programme with a miniproject component.

Module Dependencies
Pre Requisite Modules
None
Co Requisite Modules
None
Incompatible Modules
None

Coursework Assessment Breakdown %
Course Work / Continuous Assessment 100 %

Coursework Assessment Breakdown

Description Outcome Assessed % of Total Assessment Week
Practical Evaluation Observation assessment of practical skills. 1,2 20 Week 1
Open Book Exam Exam at end f day 1 of lab. practicals. 1,2,3 20 Week 1
Open Book Exam Exam at end of day 2 of lab. practicals. 1,2,3,4 20 Week 1
Project Research project based around the lab. practicals. 1,2,3,4,5 40 Week 14


End Exam Assessment Breakdown

Description Outcome Assessed % of Total Assessment Week


Distance Learning Mode Workload

Type Location Description Hours Frequency Avg Weekly Workload

Total Average Weekly Learner Workload 0.00 Hours

Part Time Mode Workload

Type Location Description Hours Frequency Avg Weekly Workload
Lecture Not Specified Preparatory study material for lab. practicals. 4 Once Per Semester 0.27
Laboratory Practical Science Laboratory Attendance at laboratory practicals. 16 Once Per Semester 1.07
Independent Learning UNKNOWN Research project based on lab. practicals. 3 Weekly 3.00

Total Average Weekly Learner Workload 1.34 Hours

Full Time Mode Workload

Type Location Description Hours Frequency Avg Weekly Workload

Total Average Weekly Learner Workload 0.00 Hours

Online Learning Mode Workload

Type Location Description Hours Frequency Avg Weekly Workload

Total Average Weekly Learner Workload 0.00 Hours

Resources
Book Resources
Walsh, Gary. 'Pharmaceutical Biotechnology'. Wiley. 2007.:-:-#160:::::-:-#160::::

Ratledge, Colin and Kristiansen Bjorn. 'Basic Biotechnology'. Cambridge Press. 2001.

Doran, Pauline M. 'Bioprocess Engineering Principles'. Academic Press. 1995.

Hatti-Kaul, Rajni and Mattiasson, Bo. 'Isolation and Purification of Proteins'. Marcel-Dekker. 2003.:-:-#160::::
Other Resources
None
Url Resources
Additional Info