Full Title BIOPROCESS ENGINEERING THEORY

Short Title BIOPROCESS ENGR THEORY

Code BIO07027
Level 07
Credit 05

Author Tobin, Kieran
Department Applied Sciences

Subject Area Bio Tech/Eng/Chem
Attendence N/A%
Fee

Description
This module aims to provide the student with a fundamental understanding of the key elements of bioprocess engineering control systems and the key role they play in the processing of modern biopharmaceutical products.

Indicative Syllabus
Process control and monitoring is a critical feature of the modern biopharmaceutical operation becasuse of the strict regulatory requirements on product release. Its applications range from status monitoring of a simple system to continuous or batch process control and reporting of a complex bioreactor process. All of these topics are explored in this module which starts with an overview of a typical control system and its principla components. The programme material will include the some or all of the following topics:
  • The business case and strategic perspective for using process monitoring and control.
  • The design and implementation of control system components including process controllers, actuators, valves etc.
  • The analysis of a variety of practical process control design strategies.
  • The main bioprocess control loops with associated equipment and control technologies.
  • The architecture, operation and programming of a typical PLC system.
  • The application of PLC control theory for a typical bioreactor control system.
  • SCADA systems, their design and application for bioprocessing control and monitoring.



Learning Outcomes
On completion of this module the learner will/should be able to
  1. Explain the business case and overall critical importance for the design of process control systems in bioprocessing.

  2. Outline the main control system components including process controllers, actuators, feedback sensors etc.

  3. Explain the operation of a modern PLC system, how the inputs and outputs are connected to it and how a programme is executed from it.

  4. Describe the principal control loops and their associated equipment for an overall biopharmaceutical manufacturing process covering both upstream and downstream bioprocesses.

  5. Discuss the principal monitoring and control systems is use for biopharmaceutical processes.

  6. Describe the application of PLC control technology for a typical bioreactor control application e.g. a PID temperature control loop.

  7. Explan the role and operation of SCADA (supervisory control and data acquisition) systems for modern bioprocesses.


Assessment Strategies
A variety of assessment strategies will be employed for this module including the following: online exams/quizzes, assignments, final written exam paper.

Module Dependencies
Pre Requisite Modules
None
Co Requisite Modules
None
Incompatible Modules
None

Coursework Assessment Breakdown %
Course Work / Continuous Assessment 60 %
End of Semester / Year Formal Examination 40 %

Coursework Assessment Breakdown

Description Outcome Assessed % of Total Assessment Week
Continuous Assessment Online Exam. 1,2,3,4,5,6 30 OnGoing
Assignment Research Topic. 4,5,7 30 OnGoing


End Exam Assessment Breakdown

Description Outcome Assessed % of Total Assessment Week
Final Exam 1,2,3,4,5,6,7 40 End of Term


Distance Learning Mode Workload

Type Location Description Hours Frequency Avg Weekly Workload

Total Average Weekly Learner Workload 0.00 Hours

Part Time Mode Workload

Type Location Description Hours Frequency Avg Weekly Workload
Lecture Not Specified Online 1 Weekly 1.00
Directed Learning Not Specified Course Notes/Slides 3 Weekly 3.00
Independent Learning UNKNOWN Mini Research Assignment 3 Weekly 3.00

Total Average Weekly Learner Workload 4.00 Hours

Full Time Mode Workload

Type Location Description Hours Frequency Avg Weekly Workload

Total Average Weekly Learner Workload 0.00 Hours

Online Learning Mode Workload

Type Location Description Hours Frequency Avg Weekly Workload

Total Average Weekly Learner Workload 0.00 Hours

Resources
Book Resources
Doran, P.M., Bioprocess Engineering Principles, Academic Press, 2006.
Other Resources
http://www.cheric.org/educational/control (Introduction to process control; understand the measurements - DP cell; Understand the actuator - control valve; PID controller tuning using various methods; Open loose response in the time and frequency domains; Closed loop PID response and stability; Feedforward and cascade control.)

http://www.pc-education.mcmaster.ca/instrumentation/go_inst.htm (Sensors, instrumentation and control valves).
Url Resources
Additional Info